Tysabri (Natalizumab) Infusion Therapy
For the most detailed information, visit Taysabri’s website.
Tysabri® (natalizumab) is an FDA-approved biologic medication given through an IV (intravenous) infusion to treat certain autoimmune conditions. It works by blocking a protein called α4-integrin, which helps prevent certain immune cells from reaching and damaging the brain, spinal cord, or digestive tract. By reducing this immune activity, Tysabri can help manage disease activity in people with multiple sclerosis (MS) and Crohn’s disease.
At Optimum Infusion, we provide Tysabri infusion therapy in a comfortable outpatient setting with experienced infusion nurses, personalized care, and close communication with your prescribing provider throughout treatment.
Relapsing forms of multiple sclerosis (MS), including:
– Clinically isolated syndrome (CIS)
– Relapsing-remitting MS (RRMS)
– Active secondary progressive MS (SPMS)
Moderately to severely active Crohn’s disease in adults
What Conditions Does Tysabri Treat?
Tysabri is approved for adults with:
What to Expect During Your Infusion
Before You Arrive
- Drink plenty of water in the days leading up to your appointment
- Eat a light meal unless your provider tells you otherwise
- Wear comfortable clothing with easy access to your arms
- Bring a book, tablet, or headphones to help pass the time
- Depending on how you feel after treatment, you may wish to arrange transportation home
During Your Appointment
Our team is here to make your experience as comfortable as possible.
- A nurse will review your medical information and answer questions
- Your arm will be cleaned and an IV line placed
- Your Tysabri infusion will typically take about 1 hour
- Your vital signs will be monitored during treatment
- Additional observation may be recommended based on medication protocols and your provider’s orders
How Often Will I Receive Tysabri?
Tysabri is given as an IV infusion every 4 weeks. Each infusion takes about 1 hour, with at least 1 hour of observation afterward, especially during your first 12 infusions, when infusion reactions are most likely.
| Infusion Duration | Typical Frequency |
| ~1 hour (plus 1 hour observation) | Every 4 weeks |
Common Side Effects
Common side effects of Tysabri include:
Important: TOUCH® Program required.
Because Tysabri carries a Boxed Warning for a rare but serious brain infection called progressive multifocal leukoencephalopathy (PML), it can only be prescribed and infused through the FDA’s TOUCH® Prescribing Program. Your prescriber, our infusion center, and the dispensing pharmacy are all enrolled. You will be screened for JC virus antibodies before treatment and monitored throughout.
Notify your nurse or prescribing provider promptly if you experience concerning symptoms during or after treatment. This list is not exhaustive, please visit Tysabri’s site for a complete list of side effects.
Headache
Fatigue
Joint or limb pain
Urinary tract infections
Upper & Lower respiratory infection
Stomach discomfort
Depression
Rash or itching
Vaginitis
Infusion-related reactions
How to Get Started
Your Provider Will Send
- Your diagnosis and supporting medical records
- Clinical documentation required by your insurance
- TOUCH® Prescribing Program enrollment
- JC virus antibody test results, when required
- Provider information, including signature and NPI
Every infusion requires a physician’s order.
You’ll Provide
- Your contact information
- Current insurance information
- Enrollment in the TOUCH® Prescribing Program
Once we receive your referral, our patient access team will begin insurance verification and prior authorization. We’ll work closely with your provider’s office and keep you informed throughout the process.
Why Choose Optimum Infusion?
Receiving infusion therapy shouldn’t add more stress to your life. Our goal is to make every visit comfortable and easy.
- Clear communication with your prescribing provider
- Comfortable infusion spaces with privacy dividers for a more personal experience
- Comfortable recliners with room for a guest
- Complimentary Wi-Fi and snacks
- Experienced infusion nurses focused on your care
- Insurance support and prior authorization assistance
- Convenient scheduling and free parking
- Wheelchair accessible
Ready to Schedule?
If you or your provider are interested in getting you infusion therapy at Optimum Infusion, we’re here to make the process easy.
Helpful Resources
- U.S. Food and Drug Administration. Tysabri (natalizumab) Prescribing Information. Biogen, Inc. https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/125104s984lbl.pdf
- Biogen. TYSABRI® — Patient Information. https://www.tysabri.com/
- Biogen. TYSABRI® — Dosing & Administration (HCP). https://www.tysabrihcp.com/en_us/home/get-started-with-support/dosing-administration.html
This information is for general education and isn’t medical advice. Your prescribing provider decides whether a therapy is right for you. If you have questions about your treatment, talk with your provider.