Skyrizi (Risankizumab) Infusion Therapy
For the most detailed information, visit Skyrizi’s website.
Skyrizi® (risankizumab-rzaa) is an FDA-approved biologic medication used to treat certain inflammatory bowel diseases. It works by blocking interleukin-23 (IL-23), a protein that plays an important role in the inflammation that causes Crohn’s disease and ulcerative colitis. By reducing inflammation, Skyrizi can help manage symptoms and support long-term disease control.
At Optimum Infusion, we provide Skyrizi infusion therapy in a comfortable outpatient setting with experienced infusion nurses, personalized care, and close communication with your gastroenterologist throughout treatment.
Moderately to severely active Crohn’s disease in adults
Moderately to severely active ulcerative colitis in adults
What Conditions Does Skyrizi Treat?
For inflammatory bowel disease, Skyrizi starts with IV infusions during induction, then transitions to subcutaneous injections for maintenance. The IV phase is used for:
What to Expect During Your Infusion
Before You Arrive
- Drink plenty of water in the days leading up to your appointment
- Eat a light meal unless your provider tells you otherwise
- Wear comfortable clothing with easy access to your arms
- Bring a book, tablet, or headphones to help pass the time
- Depending on how you feel after treatment, you may wish to arrange transportation home
During Your Appointment
Our team is here to make your experience as comfortable as possible.
- A nurse will review your medical information and answer questions
- Your arm will be cleaned and an IV line placed
- Your Skyrizi infusion will typically take about 1 hour for Crohn’s disease or about 2 hours for ulcerative colitis
- Your vital signs will be monitored during treatment
- Additional observation may be recommended based on medication protocols and your provider’s orders
How Often Will I Receive Skyrizi?
You will receive three IV infusions during the induction phase — at weeks 0, 4, and 8. After that, you switch to subcutaneous injections (at home or in clinic) every 8 weeks, starting at week 12. The IV infusion length depends on your condition:
| Infusion Duration | Typical Frequency |
| ~1 hour (Crohn’s) or ~2 hours (UC) | Every 4 weeks for 3 doses (Weeks 0, 4, and 8), then transition to subcutaneous maintenance |
Common Side Effects
Common side effects of Skyrizi include:
Notify your nurse or prescribing provider promptly if you experience concerning symptoms during or after treatment. This list is not exhaustive, please visit Skyrizi’s site for a complete list of side effects.
Upper respiratory infections
Headache
Joint pain
Abdominal pain
Injection-site reactions
Fever
Back pain
Urinary tract infection
How to Get Started
Your Provider Will Send
- Your diagnosis and supporting medical records
- Clinical documentation required by your insurance
- Tuberculosis screening results and any other required laboratory testing
- Provider information, including signature and NPI
Every infusion requires a physician’s order.
You’ll Provide
- Your contact information
- Current insurance information
Once we receive your referral, our patient access team will begin insurance verification and prior authorization. We’ll work closely with your provider’s office and keep you informed throughout the process.
Why Choose Optimum Infusion?
Receiving infusion therapy shouldn’t add more stress to your life. Our goal is to make every visit comfortable and easy.
- Clear communication with your prescribing provider
- Comfortable infusion spaces with privacy dividers for a more personal experience
- Comfortable recliners with room for a guest
- Complimentary Wi-Fi and snacks
- Experienced infusion nurses focused on your care
- Insurance support and prior authorization assistance
- Convenient scheduling and free parking
- Wheelchair accessible
Ready to Schedule?
If you or your provider are interested in getting you infusion therapy at Optimum Infusion, we’re here to make the process easy.
Helpful Resources
- U.S. Food and Drug Administration. Skyrizi (risankizumab-rzaa) Prescribing Information. AbbVie Inc. https://www.rxabbvie.com/pdf/skyrizi_pi.pdf
- AbbVie. SKYRIZI® — Crohn’s and UC Dosing (HCP). https://www.skyrizihcp.com/gastroenterology/ulcerative-colitis/dosing/skyrizi-dosing-for-uc
This information is for general education and isn’t medical advice. Your prescribing provider decides whether a therapy is right for you. If you have questions about your treatment, talk with your provider.